Search results for "design [detector]"
showing 10 items of 419 documents
A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies
2011
The aim of the present work was to develop a new mathematical method for estimating the area under the curve (AUC) and its variability that could be applied in different preclinical experimental designs and amenable to be implemented in standard calculation worksheets. In order to assess the usefulness of the new approach, different experimental scenarios were studied and the results were compared with those obtained with commonly used software: WinNonlin® and Phoenix WinNonlin®. The results do not show statistical differences among the AUC values obtained by both procedures, but the new method appears to be a better estimator of the AUC standard error, measured as the coverage of 95% confi…
Latin hypercube sampling with inequality constraints
2010
International audience; In some studies requiring predictive and CPU-time consuming numerical models, the sampling design of the model input variables has to be chosen with caution. For this purpose, Latin hypercube sampling has a long history and has shown its robustness capabilities. In this paper we propose and discuss a new algorithm to build a Latin hypercube sample (LHS) taking into account inequality constraints between the sampled variables. This technique, called constrained Latin hypercube sampling (cLHS), consists in doing permutations on an initial LHS to honor the desired monotonic constraints. The relevance of this approach is shown on a real example concerning the numerical w…
Lattices and dual lattices in optimal experimental design for Fourier models
1998
Number-theoretic lattices, used in integration theory, are studied from the viewpoint of the design and analysis of experiments. For certain Fourier regression models lattices are optimal as experimental designs because they produce orthogonal information matrices. When the Fourier model is restricted, that is a special subset of the full factorial (cross-spectral) model is used, there is a difficult inversion problem to find generators for an optimal design for the given model. Asymptotic results are derived for certain models as the dimension of the space goes to infinity. These can be thought of as a complexity theory connecting designs and models or as special type of Nyquist sampling t…
Estimating Mean Lifetime from Partially Observed Events in Nuclear Physics
2022
Abstract The mean lifetime is an important characteristic of particles to be identified in nuclear physics. State-of-the-art particle detectors can identify the arrivals of single radioactive nuclei as well as their subsequent radioactive decays (departures). Challenges arise when the arrivals and departures are unmatched and the departures are only partially observed. An inefficient solution is to run experiments where the arrival rate is set very low to allow for the matching of arrivals and departures. We propose an estimation method that works for a wide range of arrival rates. The method combines an initial estimator and a numerical bias correction technique. Simulations and examples b…
Palermo: Living Labs for Urban Regeneration
2016
The case of Palermo is described in this chapter as an example of Human Smart City (HSC) approach transferred to an extremely weak urban context in Southern Italy. The case focuses on the processes boosted through the Territorial Living Lab established in the city to tackle the topic of citizen participation in the solution of the main city challenges. It was based on a model of incremental and adaptive process of interaction, within a co-creative ecosystem, with the aim of improving housing quality. The model was shared by the players involved in the social innovation process. It would not have been possible without the Living Lab approach and the innovative momentum of design thinking tra…
Factors of Development of the Management of the Design Education in Latvia
2015
<p>The author proceeds with the discussion of significant problems in design industry and education in Europe and Latvia. This research is devoted to several important aspects in the development of design education in Latvia. Design education which is mainly based on the meaning of design as an aesthetic component of products, environment or communication, includes only a narrow range of specializations in the traditional fields of design. This concept affects the structure of design education and an beliefs of the areas in which designers will be able to work. Insufficiency of public awareness and understanding of the essence of design results in limited demand of design products and…
The Use of Game World Tasks Concepts in Higher Education
2016
The link between tasks presented in games and tasks used in higher education might have more in common than we think. Analysing how tasks work in games and applying those structures to higher education teaching can enable teachers to develop more creative, situated and exciting tasks for their students. In addition, it can improve communication and feedback. Analysis shows that tasks are an area where elements of gamification work. This article looks into the possibility of reproducing the flexibility and key components of game tasks in actual tasks in higher education. We look at the challenges and limitations and ways to solve them. Therefore, we analyse the concept of quest-logs in games…
Impact of reverse logistics on supply chain performance
2013
Purpose – The purpose of this paper is to analyse the impact of reverse logistics on order and inventory variance amplification in a single-echelon supply chain (SC) and to propose a new order policy for dampening such amplification. Design/methodology/approach – A general review of the literature on sustainable operations and on the impact of reverse logistics on SC performance provides the foundation for the study. The authors use difference equation math approach for modelling and analysing a closed SC. A proper design of experiment and data collected from the European Union statistics validate the obtained numerical results. Findings – The variability of reverse flow in a closed loop S…
Electrostatic interaction of a solute with a continuum. Improved description of the cavity and of the surface cavity bound charge distribution.
1987
Algorithms for a finer description of cavities in continuous media and for a more efficient selection of sampling points on the cavity surface are described. Applications to the evaluation of solute surface and volume and to the calculation of the solute-solvent electrostatic interaction energy, as well as of the cavitation energy are shown as examples.
Experimental research regarding the study of surface quality of aluminum alloys processed through milling
2017
The aim of this paper is to present the necessary steps to conduct a design of experiment with application on the aluminum alloy surface quality obtained by end-milling process. The machined surface quality is influenced by the cutting process parameters, and especially by their variation. The research methods used in this paper are the Taguchi method - to determine the cutting parameters influence, on the surface quality, and the full factorial design of experiment to confirm the results obtained by Taguchi’s method and to determine the percentage of the parameters influence involved in the process.